"This epidemiological bulletin aims to provide the situation of key infectious diseases in the WHO South-East Asia Region to inform risk assessments and responses. The bulletin uses information from publicly available sources and will be published every two weeks. For feedback or suggestions, please write to [email protected]. Key events and updates The first case of the mpox Clade Ib in the WHO South-East Asia Region Situation as of 29 August 2024 On 21 August 2024, Ministry of Public Health (MoPH), Thailand issued a press release about suspected case of mpox (Clade I) has been identified in a 66-year-old European patient who recently traveled from Africa. On 22 August 2024, the MoPH announced the first laboratory-confirmed case of mpox virus clade Ib detected in Thailand, and notified WHO through the National International Health Regulations (IHR) Focal Point. A total of 43 individuals who had close contact have been identified. No contacts have been reported mpox infection so far. MoPH emphasizes infection prevention and control among healthcare workers who may need to work closely with the patient, ensuring adherence to the standard operating procedures for emerging infectious diseases. Public health authorities are urging anyone who has traveled from Africa to monitor for symptoms such as fever, rash or swollen lymph nodes for 21 days and to seek medical attention immediately if these symptoms occur. This is the second confirmed case of the mpox virus clade Ib, outside of Africa. The first case was reported from Sweden..."