"There is no sign of respite in the expansion of the methamphetamine market in East and South-East Asia. Seizures of both forms of methamphetamine - tablets and crystalline - reached record highs in 2015, and most countries in the region noted increasing use of methamphetamine. • Both the number and the scale of illicit methamphetamine manufacture facilities continue to increase to meet the rapidly rising demand for methamphetamine in the region. In 2015, approximately 630 illicit synthetic drug manufacturing facilities were dismantled in the region. Of these, the majority were methamphetamine manufacturing facilities. • The retail prices of crystalline methamphetamine in countries in East and South-East Asia are high, and might be a key driver for intensified intra-regional and inter-regional methamphetamine trafficking. • Substantial quantities of precursor chemicals, which can be used for manufacture of methamphetamine, have been seized in the region with recent trends indicating a diversification of precursors and methods used. • Tablets sold as “ecstasy” in the region contain various substances other than MDMA, including new psychoactive substances (NPS). • The production of opiates in the region has been relatively stable between 2013 and 2015 but remains at a comparatively high level. Heroin trafficking and use remains a key concern in the region. • A wide range of new psychoactive substances have been identified in East and South-East Asia. These include potent synthetic opioids, such as derivatives of fentanyl , which have been implicated in the ongoing opioid overdose crisis in North America..."