Key Points: • Myanmar has serious drug use problems, largely related to unsafe practices such as needle sharing by injecting heroin users. The country?s current approach to addressing drug-related problems focuses on repression, mainly by arresting and incarcerating drug users. This paper analyses the impact of drug law enforcement practices on drug users in Myanmar. It shows the failure of the current drug law enforcement system, with drug users and their families as the principal victims. • The criminalisation of drug use and possession for personal use is heavily impacting the lives of drug users and their families. It is cause for stigmatisation by the community they live in; it increases risky drug use behaviour, and is the basis for police harassment and corruption. • The vast majority of arrests made as a result of drug laws concern drug users and small dealer/users. Prisons are overcrowded with drug users sentenced to excessively long jail terms. Prisons and labour camps lack appropriate health care and do not provide for the basic needs of inmates. Very few large-scale traffickers are targeted for arrest or have been put in prison. • Female drug users, in particular, have received very little support to face their problems. Often abandoned by their families and communities, female drug users are in need of services targeting their specific needs. • Instead of a repressive approach, voluntary and evidence-based treatment and public health services, including harm reduction, should be made available to people who use drugs. Harassment by enforcement officials and corruption in the justice system should be addressed. A harm reduction approach needs to become generally accepted by enforcement officials and by the community at large. Myanmar?s drug laws should be reformed to address these issues, and support drug users and other marginalised communities affected by drugs instead of punishing them.